University of East Anglia Featured PhD Programmes
Engineering and Physical Sciences Research Council Featured PhD Programmes
University of Kent Featured PhD Programmes
University of Warwick Featured PhD Programmes
De Montfort University Featured PhD Programmes

Investigating the mechanobiological mechanisms of cancer

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Cancer is the second-leading cause for death globally and there is a high demand for novel approaches to understand and treat cancer. Only recently it has become clear that mechanical forces play an important role in cancer initiation but in particular in cancer progression. Forces are for example exerted on cancer cells by the surrounding tissue and extracellular matrix, but the growing tumor is also generating mechanical forces itself. Currently, there are many open questions how these forces are sensed (mechanosensing) and how mechanical forces are translated into biochemical signalling. Targeting these signalling pathways is an important novel cancer therapy strategy. This project aims in particular to understand the role of extracellular matrix stiffness in tumor progression. The project will investigate the mechanisms how extracellular matrix stiffness is sensed, how it regulates mechanotransduction and how this contributes to cancer cell proliferation and migration. Our research will likely identify novel drug targets enabling innovative cancer therapy strategies.

Techniques: Live-confocal microscopy, super-resolution microscopy, 2D and 3D cell cultures, hydrogels of different stiffness, proximity biotinylation experiments combined with mass spectrometry, western-blotting, RNA-seq. experiments

Science Graduate School
As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs to learn more

Funding Notes

Entry requirements
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD, you must complete the University's application form using the following link: View Website

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.

References

Mechanics, malignancy, and metastasis: the force journey of a tumor cell.
Kumar S, Weaver VM.
Cancer Metastasis Rev. 2009 Jun;28(1-2):113-27. doi: 10.1007/s10555-008-9173-4. Review.

The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.
Muncie JM, Weaver VM.
Curr Top Dev Biol. 2018;130:1-37. doi: 10.1016/bs.ctdb.2018.02.002. Epub 2018 Mar 21. Review.

How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2020
All rights reserved.