Shortlisted eligible studentship applicants, will be notified within two-three weeks of the application deadline. Formal studentship interviews will usually be held within three-four weeks of the application deadline.
The funding for the project will cover home/EU tuition fees and a yearly stipend.
Perry et al & Williams (2019) A new mechanism for Cannabidiol in regulating the one-carbon cycle and methionine levels in Dictyostelium and in mammalian epilepsy models, British Journal of Pharmacology, In Press
Schaf, Damstra-Oddy & Williams (2019) Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products. Int. J. Dev Biol. In Press
Williams & Andrews (2019) Advice on avoiding the Valley of Death: Insights from a 3Rs model of aversive and emetic compound identification. ALTEX, doi:10.14573/altex.1810182, In Press (see here)Warren, Walker, Williams, 2018. All You Need Is Fats-for Seizure Control: Using Amoeba to Advance Epilepsy Research. Front Cell Neurosci. 12, 199.
Cocorocchio et al., 2018. Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum. Dis Model Mech. 11.
Kelly et al., 2018. Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in Dictyostelium discoideum. Dis Model Mech. 11.
Otto, Sharma, Williams, 2016. Non-Catalytic Roles of Presenilin Throughout Evolution. J Alzheimers disease
Chang et al., 2015a. Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. J. Pharmacol. Exp. Ther. 352, 43-52.
Chang et al., 2015b. Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. J Pharmacol Exp Ther. 352, 43-52.
Ludtmann et al., 2014. An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci. 127, 1576-84.
Chang Walker, Williams, 2014. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol. Dis. 62, 296-306.
Chang et al., 2013. Seizure control by ketogenic diet-associated medium chain fatty acids. Neuropharmacology. 69, 105-114.
Chang et al., 2012. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. Dis. Model. Mech. 5, 115-124.
Williams et al., 2006. Towards a molecular understanding of human diseases using Dictyostelium discoideum. Trends Mol. Med. 12, 415-424.
Williams et al., 2002. A common mechanism of action for three mood-stabilizing drugs. Nature. 417, 292-295.
FTE Category A staff submitted: 24.00
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