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Investigating the pathogenesis of pancreatic beta cell dysfunction in type 2 diabetes

About This PhD Project

Project Description

Normal glucose levels is tightly controlled by the actions and secretion of insulin. After a meal, pancreatic β-cells secrete insulin, which not only promotes glucose uptake in skeletal muscle and adipose tissues but also inhibits glucose production in the liver. This inter-tissue coordination maintains glucose level within a narrow range, and its disruption causes type 2 diabetes mellitus (T2DM). World Health Organization established that this chronic and incurable metabolic disease afflicts more than 420 million individuals worldwide, and will even further increase because of rapid projection of obesity in the next decade. Overt T2DM only occurs when pancreatic β-cell function compromises, featured by reduction of β-cell mass and defective insulin secretion, which no longer compensates for the peripheral insulin resistance. These highlight the urgent need for thorough understanding of the pathogenesis of β-cell failure and for developing therapeutic strategies against T2DM through relieving β-cell dysfunction.

This project will employ "omics" approach and different genetically modified mouse models to identify novel pathogenic pathway(s) that contributes to β-cell dysfunction. The ultimate goal is to identify novel therapeutic target for the treatment of T2DM.

About supervisor:




About The Hong Kong Polytechnic University (PolyU):

QS World University Rankings: 91
QS Top 50 under 50: 6

PolyU is a government-funded university in the Hong Kong Special Administrative Region of the People’s Republic of China. We are the largest publicly funded tertiary institution in Hong Kong in terms of student population. We have over 28,000 students with around 1,800 research postgraduate (mostly PhD) students. We have an international community with over 1,000 international students on campus from over 40 countries and over 1,300 academic staff, most of them are recruited globally and experienced in supervising research postgraduate students.

Our University has a long and proud history of providing internationally competitive professionally oriented education. We have a strong team of academic staff with solid experience in supervising research postgraduate students. In 2017/18, there are 757 Assistant Professors and above. Among them, 181 are Chair Professors or Professors. In addition, many of our Chair Professors/Professors are internationally leading experts in their research areas.

We have the largest number of students among the eight government-funded institutions in Hong Kong, and have a long and proud history of providing internationally competitive professionally oriented education.

We conduct world-class research in a large number of areas and our research emphasises high application value.

Studentship: ~2400 USD- 3300 per month (Depended on your qualitification and which PhD program you enrolled, detail can be obtained via email/discussion)

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