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Investigating the regulation of the RNA modifying enzyme ADAR1 and how it regulates other biological pathways and diseases


CEITEC

About the Project

The ADAR enzymes convert adenosine into inosine in dsRNA. Inosine is one of the most abundant and best studied modifications found in different classes of RNA. Hundreds of millions of positions have been identified within the human transcriptome where inosine can occur. The fact that levels of inosine have been found to increase in the RNAs of many cancers has sparked huge interest in this field. The levels of inosine in RNA have also been shown to profoundly affect activation of innate immunity in cancer, infection, and autoimmune diseases. The goal of this PhD project is to understand how ADAR1 is regulated and it in turn regulates different cellular processes. The methods used will include basis molecular biology techniques such as immune-blotting, RNA isolation, qPCR, cell culture etc. The candidate will have to be proficient in English, both spoken and written, be experienced in molecular biology or immunology.

HOW TO APPLY: Register for this call using the registration form at http://ls-phd.ceitec.cz/http-ls-phd-ceitec-cz/ and submit required documents to receive support with the preparation of the application and all formalities. Your application package will be forwarded to the supervisor for preliminary revision.
Applicants who wish to pursue a degree at the CEITEC PhD program must hold the equivalent of a Master’s degree (MSc) in similar field (four- or five-year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.



Funding Notes

Admission for studies, student registration for the full-time study program and proper fulfilment of student duties constitute the student’s right to a regular income of 22 000 CZK (850 EUR). Information is available at View Website

Living costs and other practicalities available at View Website

References

1 Mannion, N. M. et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep 9, 1482-1494, doi:10.1016/j.celrep.2014.10.041 (2014).
2 Rice, G. I. et al. Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. Nature genetics 44, 1243-1248 (2012).
3. M. A. O'Connell, et al. The Epitranscriptome and Innate Immunity. PLoS Genet 11, e1005687 (2015).
4. A. Gallo et al. ADAR RNA editing in human disease; more to it than meets the I. Hum Genet 136, 1265-1278 (2017).

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