About the Project
This PhD project will involve studying these special DNA structures in the genome. Based on our work which discovered multiple sequences in the genome which can form special, four-stranded, i-motif structures. This project will involve characterising the properties of these sequences using biophysical (UV, circular dichroism, NMR spectroscopy) and biological techniques (cell culture, reporter gene and gene expression assays). There will be the opportunity to work and collaborate with other research groups across the Norwich Research Park.
Applicants will have, or expect to obtain a first class, 2(i) or equivalent Honours degree in Chemistry, Biochemistry, Pharmacy, Biology, Natural Sciences or a related area.
Informal enquiries are welcomed; for further information please contact Dr Zoë Waller ([Email Address Removed])
Project supervisor: http://www.uea.ac.uk/pha/waller
Type of programme: PhD
Start date: October 2020
Mode of study: Full-time
A bench fee is also payable on top of the tuition fee to cover specialist equipment or laboratory costs required for the research. Applicants should contact the primary supervisor for further information about the fee associated with the project.
ii) Brooks, TA; Kendrick, S; Hurley, L; Making sense of G-quadruplex and i-motif functions in oncogene promoters FEBS J. 2010, 277 (17) 3459-69.
iii) Day, HA; Pavlou, P; Waller, ZAE; i-Motif DNA: structure, stability and targeting with ligands. Bioorg Med Chem. 2014, 22 (16) 4407-18.
iv) Wright, EP; Huppert, JL; Waller , ZAE; Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH Nucleic Acids Research, 2017, 45, (6) 2951–2959.
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