Dr F Cabreiro
No more applications being accepted
Competition Funded PhD Project (Students Worldwide)
About the Project
A PhD Studentship is available at the MRC London Institute of Medical Sciences, under the supervision of Dr Filipe Cabreiro (Host-Microbe Co-Metabolism Group).
Animals typically live in close association with commensal and symbiotic microbes (the holobiont). Recent studies have revealed that the metabolic status of the gut microbiota can determine nutrition-related syndromes such as obesity and type-2 diabetes, and perhaps ageing. However, to-date we know very little about how such interactions are regulated. In fact, the suspected role of host-microbiota interactions in human disease and regulation of metabolism is largely derived from observational and computational studies, and it is often difficult to establish whether changes in microbiota are cause or effect of pathology. Therefore, we lack a deep understanding of how microorganisms can precisely regulate the response of key components in metabolic health and longevity in humans.
To address this question, our lab developed high-throughput screening pipelines with the potential to unravel complex diet-microbe-host interactions. Further, our research combines a tractable genetic ageing research model - the nematode C. elegans and mouse models for studying evolutionarily conserved processes that can be translated to humans. The student will employ classical and advanced microbial genomics, high-throughput genomic/chemical screens with targeted metabolomics at the holobiont level and a systems computational approach to identify mechanisms in bacteria (e.g. signalling/biochemical pathways) that alter microbial metabolite availability with the capacity to regulate host metabolism and ageing.
Group website:
https://lms.mrc.ac.uk/research-group/host-microbe-co-metabolism/
www.cabreirolab.org
Funding Notes
This project is competition funded for students worldwide.
If successful the student would receive full tuition fee payment for 3.5 years as well as a tax free stipend amounting to £21,000pa paid in monthly instalments for the duration of their studentship.
Whilst Overseas Students are eligible, funding is more limited so only exceptional OS students will be considered.
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