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Investigating the role of senescence in musculoskeletal ageing


   School of Physiology, Pharmacology & Neuroscience

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  Dr C L Hammond, Dr Bernadette Carroll  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Collaborators: Prof Jon Tobias (University of Bristol), Prof Lorna Harries (University of Exeter)

The accumulation of senescent, ‘zombie’ cells occurs in many tissues with age, including bone, causing damage and dysfunction. This PhD project will use in vitro cell culture models, biochemistry and cell biology, as well as in vivo zebrafishodels to investigate how growth, metabolism and survival pathways are different in healthy and senescent cells. Alongside, we will investigate how senescence contributes to age‐related changes in the ability of bone to properly repair and regenerate in response to assaults. We will use this knowledge to develop novel interventions to ‘kill’ senescent cells and test whether this improves or rejuvenates ageing bones. Overall we are working to understand and improve healthy ageing. 

Our aim as the SWBio DTP is to support students from a range of backgrounds and circumstances. Where needed, we will work with you to take into consideration reasonable project adaptations (for example to support caring responsibilities, disabilities, other significant personal circumstances) as well as flexible working and part‐time study requests, to enable greater access to a PhD. All our supervisors support us with this aim, so please feel comfortable in discussing further with the listed PhD project supervisor to see what is feasible.  

Information on “How to Apply” is available here:  https://www.swbio.ac.uk/programme/projects-available/. When applying to the University of Bristol, please use the following link: Start your application | Study at Bristol | University of Bristol. To choose the correct programme, please start to type 'South West' in the search box and the SWBio programme will appear. When making your application, please indicate the supervisor name and the project title on the form. Ensure you provide all supporting documents as per the programme admissions statement.


Funding Notes

Application deadline: Midnight, Monday 5 December 2022
This is a 4 year PhD studentship fully funded by the BBSRC, SWBio Doctoral Training Partnership. Full details on the BBSRC SWBio DTP programme can be found at: https://www.swbio.ac.uk/programme/projects-available/. This link includes information on projects available, eligibility requirements and the selection process.

References

pubmed.ncbi.nlm.nih.gov/34465741/

Review:
pubmed.ncbi.nlm.nih.gov/33484578/

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