The Fibroblast Growth Factor (FGF) signalling pathway plays critical roles in regulating cell lineage during normal development and stem cell differentiation in culture. FGF signalling is also important in adult homeostasis and is often misregulated during the development of cancer. We have a good understanding of the developmental processes and target genes regulated by FGF signalling during early amphibian development. However, several different members of the FGF family of ligands and receptors are expressed in early development and, at present, it is not clear what role each individual FGF or FGF receptor has in mediating the effects of FGF signalling. We will use Cas9/CRISPR mediated gene editing to investigate the developmental effects of inhibiting individual FGF ligands and receptors. The project will provide excellent training in the research process and the candidate will gain experience in a wide range of embryological and molecular biological approaches to investigating gene expression and function in early development.
Funding Notes
This is a self-funded project. Applicants need to have adequate funds to meet the costs of a self-funded research project including tuition fees and living expenses for the duration of the research programme. Please see information on tuition fee costs, living expenses and funding opportunities.
References
Applications are welcome for a 1-year MSc by Research.
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