USP17 is over-expressed in a range of primary tumours including NSCLC, breast, colorectal, cervical, ovarian and osteosarcoma and its depletion has been shown to block the growth, and migration, of cells from all these cancer types. As a result, USP17 represents a potential therapeutic target in these cancers.
Therefore, our lab has been working to explore the function of USP17 to help us understand why it is important in these cancers, and how targeting this deubiquitinase will impacts upon cancer and normal cells. We have shown that USP17 is required for the normal trafficking of a number of receptors (Jaworski et al., 2014; McCann et al, 2019) and proteins (Jaworski et al, 2014) within the cell, and we have identified potential mechanisms by which USP17 can regulate intracellular trafficking. Therefore, this project will further investigate the regulation of intracellular trafficking by USP17 in both normal and cancer cells.
The student will be part of a cross-disciplinary team based in the School of Pharmacy with Dr Burrows. The student will have the opportunity to learn a broad range of molecular and cell biology techniques. This project will also allow the student to gain skills in written and verbal scientific presentation skills.