About the Project
About the Award
Professor Chrissie Thirlwell, University of Exeter
College of Medicine and Health, Exeter
The University of Exeter’s College of Medicine and Health, is inviting applications for a fully-funded PhD studentship to commence in September 2021 or as soon as possible thereafter. For eligible students the studentship will cover Home tuition fees plus an annual tax-free stipend of at least £15,609 for 3 years full-time, or pro rata for part-time study. The student would be based in the College of Medicine and Health at the RILD Building, RD&E Hospital Wonford in Exeter.
Diabetes and metabolic disorders are risk factors for certain cancers, however their effect on tumour biology and tumour evolution is not fully understood. This project aims to investigate alterations in the genetic sequence and epigenome in tumours of people with type 2 diabetes and metabolic disorders. This will be achieved by assessing genome-wide DNA methylation and sequence variation using a variety of techniques, including methylation microarrays and whole genome sequencing on Nanopore and other next generation sequencing platforms. This will allow us to identify novel molecular subgroups of cancer, new therapeutic targets and help to improve screening and risk stratification, in a step towards precision medicine.
The project will involve generation of some novel data, and integration with existing whole genome sequencing datasets. The student will gain skills both in wet lab experiments, and extensive experience of bioinformatics data analysis. The project will also give the opportunity to link with real world clinical data through the Genomics England Clinical Interpretation Partnerships (GeCIPs) and the Genomic Laboratory Hubs, in partnership with the NHS.
The supervisory team combines world leading expertise in cancer biology and epigenomic analysis, and will involve collaborations with internationally renowned leaders in diabetes, glycemic traits and colorectal cancer research.
This award provides annual funding to cover Home tuition fees and a tax-free stipend. For students who pay Home tuition fees the award will cover the tuition fees in full, plus at least £15,609 per year tax-free stipend. Students who pay international tuition fees are eligible to apply, but should note that the award will only provide payment for part of the international tuition fee and no stipend.
How to apply
In the application process you will be asked to upload several documents.
• Letter of application (outlining your academic interests, prior research experience and reasons for wishing to undertake the project).
• Transcript(s) giving full details of subjects studied and grades/marks obtained (this should be an interim transcript if you are still studying)
• Two references from referees familiar with your academic work. If your referees prefer, they can email the reference direct to [Email Address Removed] quoting the studentship reference number.
• If you are not a national of a majority English-speaking country you will need to submit evidence of your proficiency in English.
The closing date for applications is midnight on 31/05/2021. Interviews will be held virtually in the week commencing 05/07/2021
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