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Investigation of Formulation Design Solutions for Low Global Warming Potential Pulmonary Drug Delivery Systems

   Faculty of Life Sciences

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  Dr Richard Telford, Dr Colin Seaton, Prof Tim Gough  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

In 1987 the Montreal Protocol defined a pathway to eliminate the compounds proven to be harmful for the ozone, such as chlorofluorocarbon (CFC) employed as propellants in pressurised metered dose inhalers (pMDIs). Since the adoption of the Kyoto Protocol in 1997 and the Europe F-Gas regulation in 2015, further amendments have been proposed which aim to reduce by over 80% the use of F-gases (by 2047), known to contribute to global warming. These amendments have been foreseen to again have a great impact on the pharmaceutical industry and, particularly, on products for inhalation which contributes for a low 2.4% of the total F-gases emissions. It is now clear therefore there is a real need for alternatives to the current reliever pMDIs that are both affordable and exhibit a lower global warning potential (GWP).

The 3 (+1) year PhD programme will investigate the fundamental properties of selected low GWP propellants used in the formulation of pMDIs. These investigations will be undertaken using a combination of traditional chemical analysis (NMR, Cascade Impaction, chromatography, X-ray diffraction, microscopy etc.) computational approaches and engineering based methods to better understand the performance and fundamental behaviours of the APIs and propellants themselves.

Funding Notes

The 3 (+1) year PhD programme is fully funded by an industrial partner of the University of Bradford, and includes all fees including a bench fee of £10,000 (in years 1 to 3). A stipend of up to £16,062 per year (UKRI rates) is also offered.
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