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Investigation of neuro-immune-stromal cell interactions in Severe Asthma

   National Heart and Lung Institute

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  Prof C Lloyd  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

“Investigation of neuro-immune-stromal cell interactions in Severe Asthma”

3-year-funded PhD post in Professor Clare Lloyd's Lab, NHLI, Imperial College London– starting October 2021

Applications are invited from candidates with a Master’s degree (Merit and above) in Immunology, Biomedical Sciences, Cell biology, or a related discipline, for a 3 year PhD.

The studentship will be funded for 3 years with a tax-free bursary of £21,000 p.a. Tuition fees at the Home rate will also be paid.

Summary of Research

This PhD aims to uncover the molecular mechanisms that underlie key pathological processes in severe asthma. Asthma is a heterogeneous disease that is divided into sub-categories based on clinical phenotype. Severe asthma is characterised by chronic airway inflammation, airway remodelling and abnormal lung function. Environmental factors such as pollutants and pathogens are instigators of injury and contribute to asthma severity, but it is unclear how and why the body’s response to such exogenous stimuli remains aberrant in asthmatics.

Therefore, this PhD will investigate the disruption of neuro-immune-stromal interactions in asthmatics to usually innocuous inhaled particles, facilitating chronic airway inflammation and detrimental tissue remodelling. To do this the successful candidate will use both patients and neonatal/adult allergic airway mouse models to determine immune-neuro-stromal interactions and assess their impact on disease progression, pathology and lung function.

Imperial College London provides excellent opportunities for research students' training. All students benefit from a full programme of training in research and transferable skills organised through the Graduate School, the quality of which has been recognised several times at the Times Higher Education (THE) Awards.

The student will be based in Professor Clare Lloyd’s group located at Imperial’s South Kensington campus that is part of the Inflammation, repair and development (IRD) section within the National Heart and Lung Institute. The student will benefit from this exciting environment that brings together clinical and academic researchers, with access to state-of-the-art facilities and excellent opportunities for PhD student training and development.

 How to Apply

Applicants must hold, or expect to obtain, a first or upper second-class undergraduate degree or UK equivalent, along with a Masters, both in an appropriate subject from a recognised academic institution. To apply please send a CV, a one-page personal statement, and the names and addresses of at least two academic referees to Dr Laura Yates, Research Manager to the Lloyd group, by email [Email Address Removed].

 Please note that candidates must fulfil College admissions criteria.

 Application deadline: 30th June 2021

Funding Notes

The studentship will be funded for 3 years with a tax-free bursary of £21,000 p.a. Tuition fees at the Home rate will also be paid.
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