Investigation of pharmaceutical crystallisation using small angle x-ray scattering at University of Strathclyde on FindAPhD.com

Investigation of pharmaceutical crystallisation using small angle x-ray scattering

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Dr Y Chen, Prof J Sefcik Applications accepted all year round Self-Funded PhD Students Only

Glasgow United Kingdom Analytical Chemistry Bioinformatics Biomedical Engineering Biotechnology Chemical Engineering Data Analysis Medical Physics Optical Physics Materials Science Physics

About the Project

Small-angle X-ray scattering (SAXS) offers various ways to characterize nanoscale structures of pharmaceutical crystal and large molecules. The scattering of X-rays at small angles is (like light scattering) a non-invasive technique which originates from the spatial fluctuations of the electron density within the material. This allows investigating nanoparticles, molecular ordering/packing in the size range of 20 to 100 nm and in addition permits to identify the physical form of API/polymorphs and excipients in drug products. Small amounts of aggregates or crystalline material can be detected and amorphous, liquid crystalline, and crystalline structures be distinguished.

The project will focus on the applications of latest SAXS system in CMAC (EPSRC Centre of excellence in continuous manufacturing and crystallisation) to provide mechanistic understanding of interparticle interaction in dense system under repulsive or attractive interactions. The insight will be applied to optimise pharmaceutical crystallisation process to avoid undesired agglomeration during the process.

This innovative research project works with world leading experts, ideally suited to students with the creativity and drive to pursue doctoral studies at a technologically leading university.

In addition to undertaking cutting edge research, students are also registered for the Postgraduate Certificate in Researcher Development (PGCert), which is a supplementary qualification that develops a student’s skills, networks and career prospects.

Information about the host department can be found by visiting:

www.strath.ac.uk/engineering/chemicalprocessengineering

www.strath.ac.uk/courses/research/chemicalprocessengineering/

Funding Notes

This PhD project is initially offered on a self-funding basis, with partial funded provided by an industrial project. It is open to applicants with their own funding, or those applying to funding sources. However, excellent candidates may be considered for a University scholarship.

Students applying should have (or expect to achieve) a minimum 2.1 undergraduate degree in a relevant engineering/science discipline, and be highly motivated to undertake multidisciplinary research.

Where will I study?

University of Strathclyde

The University of Strathclyde is a leading international technological university, located in the heart of Glasgow – one of the UK’s largest cities and an emerging centre for commerce, tech and innovation. Founded in 1796 as a ‘a place of useful learning’, research is central to everything we do. It informs our teaching and underpins our commitment to making a positive difference to society. At Strathclyde, we don't just offer a doctoral degree - we offer an opportunity to make a real impact on the world. Strong links with business, industry, and the public sector mean that our doctoral researchers are tackling some of the most pressing local, societal, and global challenges of our time. Join a dynamic community of world-renowned academics leading cutting-edge research in Science, Engineering, Business, Humanities and Social Sciences.