About the Project
The prospective student will build on recent work in our lab by sampling volatiles from microbial cultures (Ahmed et al. 2018, Lawal et al. 2018). Samples will be analysed by gas chromatography-mass spectrometry, and together with machine learning data processing methods, produce and evaluate volatilome profiles which relate to changes in cellular metabolism, morphogenesis, antimicrobial resistance, and polymicrobial infection of human lung cell lines. Data will then be compared with exhaled breath samples collected from critically ill patients. Potential biomarkers will be further investigated to develop diagnostic tests for early identification of infection towards personalised treatment.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in Microbiology, or with an interest in Clinical Biochemistry are encouraged to apply.
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Biochemistry
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website
Ahmed WM, Geranios P, White IR, Bromley M, Lawal O, Nijsen T, Goodacre R, Read N, Fowler SJ. Development of an adaptable headspace sampling method for metabolic profiling of the fungal volatome. Analyst 2018 DOI: 10.1039/C8AN00841H Lawal O, Knobel H,
Weda H, Bos LD, Nijsen TME, Goodacre R, Fowler SJ. Volatile organic compound signature from co-culture of lung epithelial cell line with Pseudomonas aeruginosa. Analyst. 2018 Jul 7;143(13):3148-3155. doi: 10.1039/c8an00759d.
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