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Ion channel clustering in neuronal membranes


   Faculty of Biology, Medicine and Health


Manchester United Kingdom Biochemistry Biophysics Structural Biology

About the Project

The aim of the study is to investigate the organization of ion channels in the membranes of excitable cells by scaffold proteins, and to discover how the properties of the channels are modified by these interactions. The work will encompass major structural and proteomic techniques as well as techniques relevant to biotechnology including biochemical assays, protein over-expression and purification, liquid chromatography and reconstitution. The studentship will therefore use computational and structural biology techniques to investigate the molecular architecture involved in the generation of electrical signals across neuronal membrane.

Entry Requirements:
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with an interest in structural biology are encouraged to apply.

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Structural Biology.

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk

Funding Notes

Applications are invited from self-funded students. This project has a Band 2 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website View Website

References

Fomina, S., Howard, T.D., Sleator, O.K., Golovanova, M., O'Ryan, L., Leyland, M.L. Grossmann, J.G, Collins, R.F., Prince S.M “Self-directed assembly and clustering of the cytoplasmic domains of inwardly rectifying Kir2.1 potassium channels on association with PSD-95” Biochim. Biophys Acta. (2011) 1808: 2374-89.

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