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Iontophoresis to deliver corticosteroids across buccal mucosal using hydrogel as delivery systems


Project Description

Background:
Topical delivery of drugs to treat oral mucosal disease is often challenging. This is due to, for example, the saliva washing therapeutic agents away into the gastrointestinal system, the movement of oral structures during mastication and the presence of keratinized oral mucosal surfaces. There is a need to develop effective methods for treating conditions such as as Lichen planus (LP) and other severe oral conditions. A drug delivery system, which could precisely deliver the targeted drug in a controlled manner locally at the infected site, with minimal risk of significant systemic absorption, is highly attractive. Iontophoresis-mediated drug delivery is therefore of considerable interest.

Previous work by this group has demonstrated that iontophoresis enhanced the delivery of model agents from hydrogel based delivery systems and across porcine buccal mucosa. Therefore, iontophoresis appears to have the potential to be used in the mouth for the treatment of both topical and systemic conditions.

Aims:
• To develop corticosteroid containing hydrogel delivery systems and to investigate passive/iontophoresis transfer of these agents across porcine buccal mucosal tissue
• To analyse the absorption and diffusion processes associated with drug release.

How to apply:

For more information regarding the project, please contact Dr Mangala Patel ( )

Applications should be submitted through the Queen Mary application system. Please indicate the project title and supervisor in the ‘Research Degree Programmes - Additional Questions’ section of the application.

Alongside the application form, please send the following supporting documents:
• Curriculum Vitae (CV)
• Copies of your degree certificates with transcripts
• Proof of English language ability for overseas applicants from non-English speaking countries
• A one-side A4 statement of purpose. This should set out your previous academic or other experience relevant to the proposed research; why you wish to undertake this research at QMUL; your previous research or professional training and what further training you think you will need to complete a PhD; and what ethical issues you will need to consider in undertaking this research.
• Two references. At least one reference must be from an academic referee who is in a position to comment on the standard of your academic work and suitability for postgraduate level study. Where appropriate, a second referee can provide comment on your professional experience.

Please contact Charlotte Royle () with any queries about the application process.

Funding Notes

Person specification:
The project would suit a candidate with a BDS or a minimum of 2:1 degree in Biomedical Sciences, Dental Materials, Chemistry, Biochemistry or Physical Sciences.

Funding notes:
We will consider applications from prospective students with a source of funding to cover tuition fees and bench fees. Both self-funded and sponsored students will be considered.

UK and EU nationality self-funded students might be eligible for both the cost of tuition fees and a yearly stipend over the course of the PhD programme from the Student Finance England: View Website

How good is research at Queen Mary University of London in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 32.20

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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