About the Project
To compare the risks of cardiovascular events and total mortality for adults with subclinical hypothyroidism among patients who received levothyroxine and among patients who did not receive levothyroxine.
We propose to perform a clinical trial emulation. Although only adequately powered randomized controlled intervention trials would be able to demonstrate whether treatment of SCH is worthwhile in terms of improvement in both, cardiovascular disease risk and mortality, such a trial has not been performed to date and due to the long follow up period that would be needed it might never happen. Observational analyses of big databases might not the preferred choice for comparative effectiveness research however, using the adequate methods it’s possible to answer causal questions when the trial is not feasible.
The candidate should possess skills in research methods, communication and scientific writing as well as the ability to work and learn from colleagues based in multiple disciplines. The candidate should have an interest and enthusiasm for the topic and methods of the studentship. Applicants for this project must have an Undergraduate degree (1st class Honours or 2:1) or Masters degree, or equivalent, in a relevant discipline e.g. public health, epidemiology, computer science, statistics or other numerate subjects.
The successful candidate will join a multidisciplinary health data science team and will gain skills and experience in systematic evidence synthesis, epidemiology, secondary data analysis, health data science, statistics and written and verbal communication skills.
As soon as possible.
For further details on the project or informal enquiries please contact Professor Colin McCowan on
[Email Address Removed]
How to apply
Applications should be submitted via the University application system at https://www.st-andrews.ac.uk/study/apply/postgraduate/research/
Friday 28th August
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