About the Project
Assays will be performed using human tissues from consenting women undergoing routine gynaecological surgery and from mouse models in line with Local Ethics and Home Office regulations. Lipidomics will be employed to profile PGs, endocannabinoids and other bioactive lipids, immersion will be performed for tissue contraction studies and histology, ICC and molecular techniques to assess receptor and protein expression. Findings will be correlated with clinical history and patient-reported symptoms. A cell-based modelling approach will also be used to identify the pharmacological effect of prostamides and PGs on cell metabolism and growth and to assess the value of potential therapeutic compounds. This preclinical approach should provide new insights into the paracrine pathways leading to dysmenorrhoea and heavy menstrual bleeding for potential future diagnostic and therapeutic developments.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk.
This project has a Band 2 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply please visit(View Website).
2. Carrarelli, Funghi, Bruni, Luisi, Arcuri, Petraglia (2016) Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression. Gynecol Endocrinol. 32(4): 319-22.
3. Cui, Wang, Wang, Zhang, Xu, Jiang, Hao (2017) The correlation of anandamide with gonadotrophin and sex steroid hormones during the menstrual cycle. Iran HJ Basic Med Sci 20: 1268-74.
4. Glass, Hong, Sato, Mitchell (2005) Misidentification of prostamides as prostaglandins. J Lipid Res. 46(7): 1364-8.
5. Sanchez, Vigano, Mugione, Panina-Bordignon, Candiani (2012) The molecular connections between the cannabinoid system and endometriosis. Mol Human Reprod. 18(12): 563-71.
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