University of Hong Kong Featured PhD Programmes
University of Southampton Featured PhD Programmes
University of Nottingham Featured PhD Programmes

Isthmin-1 in mammary gland branching morphogenesis and breast cancer tumorigenesis

School of Biomedical Sciences

This project is no longer listed on and may not be available.

Click here to search for PhD studentship opportunities
Prof Z Zhou Applications accepted all year round Funded PhD Project (Students Worldwide)

About the Project

Isthmin-1 is a newly identified extracellular matrix protein which has been shown to be widely expressed and is critical for Nodal signaling (Osorio et al. J cell Biol. 2019).The Isthmin-1 transgenic and knockout mice have been generated to investigate its role in development and diseases. Loss of Isthmin-1 impairs mammary gland development with much less branching morphogenesis. In addition, loss of Isthmin-1 reduces tumor umber and tumor burden in breast cancer mouse model, suggesting a key role for Isthmin-1 in breast cancer development. We will take various approaches to investigate underlying mechanisms for Isthmin-1 in regulating tumor development and branching morphogenesis.

Faculty information, funding opportunities and application deadlines:
Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.

FindAPhD. Copyright 2005-2020
All rights reserved.