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Kinase regulation of HOX transcription factors – a potential target in cancer?

About This PhD Project

Project Description

The HOX genes are a family of transcription factors that have a number of important functions in cancer, including cell survival and metastasis. Despite this, relatively little is known of how these genes are regulated at the post-translational level. The aim of this project is to understand how the activity of HOX proteins can be regulated by phosphorylation in cancer cells, and how this in turn might be a target for cancer therapies.

You will be based at the Institute for Cancer Therapeutics in the School of Pharmacy and Medical Sciences, University of Bradford, an internationally competitive research centre that provides a supportive environment and has an excellent track record in PhD training and completion, and a thriving postgraduate student community. Training in the first year will include standard cell and molecular biology techniques as well as more advanced methodology including confocal and florescent microscopy. You will also be supported by an active, ongoing education program of seminars and student-led events.

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