References
KEY PUBLICATIONS:
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2. Miranda-Carús, M.-E., Balsa, A., Benito-Miguel, M., Pérez de Ayala, C., & Martín-Mola, E. (2004). IL-15 and the Initiation of Cell Contact-Dependent Synovial Fibroblast-T Lymphocyte Cross-Talk in Rheumatoid Arthritis: Effect of Methotrexate. The Journal of Immunology, 173(2). https://doi.org/10.4049/jimmunol.173.2.1463
3. Brown, F. D., Sen, D. R., LaFleur, M. W., Godec, J., Lukacs-Kornek, V., Schildberg, F. A., Kim, H.-J., Yates, K. B., Ricoult, S. J. H., Bi, K., Trombley, J. D., Kapoor, V. N., Stanley, I. A., Cremasco, V., Danial, N. N., Manning, B. D., Sharpe, A. H., Haining, W. N., & Turley, S. J. (2019). Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nature Immunology 2019 20:12, 20(12), 1668–1680. https://doi.org/10.1038/s41590-019-0515-x
4. Macaubas, C., Nguyen, K., Milojevic, D., Park, J. L., & Mellins, E. D. (2009). Oligoarticular and polarticular JIA: epidemiology and pathogenesis. Nature Reviews. Rheumatology, 5(11), 616. https://doi.org/10.1038/NRRHEUM.2009.209
5. Friščić, J., Böttcher, M., Reinwald, C., Bruns, H., Wirth, B., Popp, S.-J., Walker, K. I., Ackermann, J. A., Chen, X., Turner, J., Zhu, H., Seyler, L., Euler, M., Kirchner, P., Krüger, R., Ekici, A. B., Major, T., Aust, O., Weidner, D., … Hoffmann, M. H. (2021). The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts. Immunity, 54(5), 1002-1021.e10. https://doi.org/10.1016/J.IMMUNI.2021.03.003
KEYWORDS: Inflammation, juvenile idiopathic arthritis, tissue-resident, genomics