This PhD will explore the ability of novel scaffolds to repair ligaments in the foot and ankle and their potential to address a key clinical challenge. The project will use advanced engineering and biological techniques, including mechanical testing, joint simulation, graft fixation and imaging, to perform a detailed analysis of the underlying tissues and their injury mechanisms.
Ankle sprain is a frequent injury, damaging local soft tissues and joint surfaces and initiating a degenerative pathway. Chronic ankle instability affects over 30% of patients after a severe ankle sprain and up to 60% of those cases progress to post-traumatic osteoarthritis. Anatomic and non-anatomic reconstruction to repair and support structural soft tissues may be used where conservative treatment has failed to correct the instability. Repair of these soft tissues is challenging for many reasons, including treatment of small ligaments and bones, complex joint biomechanics and slower healing in peripheral joints.
This PhD will combine novel experimental testing and imaging methods to examine the mechanical performance of ankle ligaments and a potential replacement material. It will develop natural tissue simulation methods and biological characterisation of tissue damage mechanisms. Use and development of unique in vitro testing equipment will examine the mechanical behaviour of individual ankle ligaments and their contribution to normal function. The multidisciplinary project will use advanced imaging to identify damage patterns in collagen structures within the tissues. Evaluation of the limitations of bony fixation in the ankle will lead to novel engineering approaches to address this complex clinical challenge.
The successful candidate should have experience in mechanical engineering methods and ideally some laboratory experience. Experience in design of test methods and fixtures for biological specimens would be beneficial. Prior imaging experience is not necessary but an enthusiasm to develop a multidisciplinary understanding of tissue behaviour is critical. During the project, you will be expected to prepare and test human cadaveric tissues; previous experience in handling human or animal tissue would be beneficial, but not essential. Full training will be provided on all laboratory methods and the associated health and safety requirements.
There will be opportunities for involvement in wider activities, including clinician and patient input, public and patient engagement events, and bespoke training for medical technology (MedTech) careers. You will be encouraged to develop new skills through training provided by the University and opportunities to participate in international conferences or laboratory visits.
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