About the Project
We have isolated a number of strains of L. monocytogenes from a variety of sources, with different pathogenic potential (1). The DNA from these isolates have been sequenced and we are carrying out bioinformatic analysis to determine the presence or absence of virulence factors associated with disease. However, in silico predictions alone cannot fully define the virulence of an organism. The current project will determine the virulence of different strains of
L. monocytogenes using Galleria mellonella, a well characterised invertebrate model of virulence (2). If it is found that environmental strains demonstrate only limited disease causing potential then this will provide the industry with extra tools for managing risk and developing appropriate control mechanisms.
A first degree (at least a 2.1) ideally in microbiology, biological science, biomedical science or another relevant discipline, with a good fundamental knowledge of microbes.
English language requirement
IELTS score must be at least 6.5 (with not less than 6.0 in each of the four components). Other, equivalent qualifications will be accepted. Full details of the University’s policy are available online.
• Experience of fundamental laboratory skills
• Competent in aseptic technique
• Knowledge of microbiology
• Good written and oral communication skills
• Strong motivation, with evidence of independent research skills relevant to the project
• Good time management
Molecular Biology skills
Please quote project code SAS0074 in your enquiry and application.
• Completed application form
• 2 academic references, using the Postgraduate Educational Reference Form (Found on the application process page)
• A personal research statement (This should include (a) a brief description of your relevant experience and skills, (b) an indication of
what you would uniquely bring to the project and (c) a statement of how this project fits with your future direction.)
• Evidence of proficiency in English (if appropriate)
Food Microbiology 299:23-32. doi: 10.1016/j.ijfoodmicro.2019.03.013.
2) Sheehan G, Dixon A, Kavanagh K. 2019. Utilization of Galleria mellonella larvae tocharacterize the development of Staphylococcus aureus infection.
Microbiology. doi: 10.1099/mic.0.000813.
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