The significance of gait imperfections can be easily contemplated in competitive athletic pursuits where optimised technique can increase chances of success and reduce injury risk, as illustrated by the wide range of biomechanics-related research aiming to determine desirable sports techniques and the use of biomechanical assessment in performance enhancement and rehabilitation (Cates and Cavanaugh, 2009; Elliott, 1999; Lees, 2002). Risk of injury is high for distance runners, with evidence of further increased risk for female runners but the risk factors and mechanisms of injury, and how these might differ between males and females, are not well understood. This study aims to assess biomechanical and physiological effects of localised lower limb muscle fatigue in running at different speeds and inclines in order to evaluate strategies of musculoskeletal adaptation and injury risk. The project will utilise various measurement techniques including electromyography, dynamometry and 3D motion analysis. Although prior experience is beneficial, full training will be given.