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Long non-coding RNAs (lncRNAs) in leukemias

Faculty of Medicine

About the Project

PROJECT: We are looking for a motivated PhD student for a project funded by ERC Grant (Marek Mraz lab, The project goal is to understand the role of noncoding RNAs in the regulation of microenvironmental interactions in B cell malignancies. The lab is deciphering novel mechanisms of BCR signaling regulation mediated by microenvironmental signals, CD20, p53, and the signals from T cells (Pavlasova et al. Blood, 2016; Pavlasova et al. Leukemia, 2018). We showed for the first time that non-coding RNAs, namely microRNAs (miRNAs), regulate the BCR signaling which opened an interesting field of research (Musilova et al. Blood, 2018; Mraz et al. Blood, 2014; Cerna et al. Leukemia, 2018). Now we would like to reveal the role of lncRNAs in BCR signaling and other microenvironmental interactions of leukemias.
We have identified candidate long-noncoding RNAs (lncRNAs) that might act as novel regulators of the crosstalk of BCR signaling/T-cell interactions/adhesion in B cell malignancies. This will be further investigated by the PhD student using technics such as genome editing (CRISPRi), RNA sequencing, functional studies with various in vitro (primary cells and cell lines), and in vivo models. The research is also relevant for pre-clinical development of novel RNA-based therapeutic trials, and resistance mechanisms to BCR inhibitors.
• modern laboratories, project funded by the prestigious ERC grant = high risk and high gain, state-of-the-art instrument, stable funding, competitive scholarship
• You will work in a team of young investigators that challenge some long standing problems in the field of hematology. We do basic science, but with the objective to help patients in the future (we have access to primary samples with hem. malignancies, and we suggest novel clinical trials).

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