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Long Period Hydrogel Grating on Optical Fibre for Biosensing


Project Description

This is a joint project will bring together the expertise of Dr Ruchi Gupta (University of Birmingham, UoB) and Dr Serhiy Korposh (University of Nottingham, UoN) in hydrogel gratings [1] and optical fibres [2] to deliver a sensing platform. One potential application of the envisioned sensing platform will be in the monitoring of wound healing. Non-healing wounds are a huge economic burden currently costing £4.5-5 billion per year (i.e. ~4% of the total NHS budget).

The photofunctionalisable hydrogel will be polymerised around a silica optical fibre, following which the hydrogel will be exposed to a light-pattern to obtain an optical fibre long period grating. Recognition elements such as antibodies will be selectively immobilised in the hydrogel grating. As a result, as the analyte will bind to the recognition elements, the wavelength of light that will be reflected back will change forming the basis of sensing. Gratings of different pitch and recognition elements may be fabricated along the length of the optical fibre to sense multiple analytes. Initial studies will be performed using analytes dissolved in buffers followed by spiked synthetic and real biological samples (e.g. wound fluid). Depending on the performance of the sensing platform with biological samples, sample preparation approaches for in-situ analyte preconcentration and clean-up may also be investigated.

For informal enquiries please contact Dr Ruchi Gupta at . Please include a CV and transcripts in your email.

Degree Requirements:
Applicants should possess (or expect to possess) a good degree in physical sciences or engineering or allied disciplines.

Funding Notes

UK/ EU students only

References

[1] A.K. Pal, E. Labella, N.J. Goddard, R. Gupta , Photofunctionalisable Hydrogel for Fabricating Volume Optical Diffractive Sensors, Macromolecular Chemistry and Physics, 2019, DOI: 10.1002/macp.201900228.

[2] J. Hromadka, N. N. Mohd Hazlan, F.U. Hernandez, R. Correia, A. Norris, S.P. Morgan, S. Korposh, Simultaneous in situ temperature and relative humidity monitoring in mechanical ventilators using an array of functionalised optical fibre long period grating sensors: Sensors and Actuators, B: Chemical Sensors and Actuators, B: Chemical. 286, 306-314, 2019.

How good is research at University of Birmingham in Chemistry?

FTE Category A staff submitted: 28.00

Research output data provided by the Research Excellence Framework (REF)

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