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Longitudinal multi-omics of host–microbe dynamics in amyotrophic lateral sclerosis


Project Description

Amyotrophic lateral sclerosis (ALS, or motor neuron disease) is a rapidly progressive and invariably fatal neurodegenerative condition. ALS has a clear genetic component, but disease phenotype is variable even within families with shared genetic risk factors. This suggests significant undiscovered environmental modifiers. The microbiome is the collective genetic material contained within microorganisms living within the human gut. Discovery of a bidirectional gut-brain axis has laid the foundation for our proposed study in which we aim to:
1. Profile the gut microbiome in ALS patients and to test for differences between ALS patients and controls; and between fast and slow progressors.
2. Determine whether the gut microbiome interacts synergistically with host genetics to determine ALS status/severity.
3. Identify whether the gut microbiome modifies Riluzole bioavailability.

Funding Notes

Funding:
These studentships will be 42 months in duration, and include home fee and stipend at UKRI rate.

Eligibility:
Candidates must have a first or upper second class honors degree or significant research experience.

Enquiries:
Interested candidates should in the first instance contact Dr Johnathan Cooper-Knock ()

References

How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select 'Neuroscience' as the department.

Deadline for applications is 5pm on Wednesday 29th January 2020. Late applications will not be accepted. Interviews are scheduled to be held on Tuesday 25th February 2020.

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