FindA University Ltd Featured PhD Programmes
Engineering and Physical Sciences Research Council Featured PhD Programmes
FindA University Ltd Featured PhD Programmes

Low density lipoprotein oxidation and atherosclerosis

School of Biological Sciences

Applications accepted all year round Self-Funded PhD Students Only

About the Project

"The research in Professor David Leake’s group is concerned with atherosclerosis, the underlying cause of
coronary heart disease and strokes. We are investigating how low density lipoprotein (LDL), which
carries most of the cholesterol in blood, is oxidised (i.e. becomes ‘rancid’) and the damaging effects
that oxidised LDL has on arterial cells. Atherosclerotic lesions are inflammatory sites and contain
many macrophages. We have shown that LDL is oxidised within lysosomes in macrophages
and that this oxidation is catalysed by iron at the lysosomal pH of 4.5. The ultimate aim is to use
antioxidants targetted to lysosomes in humans to prevent atherosclerosis."


Wen, Y. & Leake, D.S. (2007) Circ. Res. 100, 1337-1343. Low density lipoprotein undergoes
oxidation within lysosomes in cells

Satchell, L. & Leake, D.S. (2012) Biochemistry 51, 3767-3775. Oxidation of low-density lipoprotein
by iron at lysosomal pH: Implications for atherosclerosis

Ahmad, F. & Leake, D.S. (2018) Chem. Phys. Lipids 213, 13-24. Antioxidants inhibit low density
lipoprotein oxidation less at lysosomal pH: A possible explanation as to why the clinical trials of
antioxidants might have failed

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Reading will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully

Search Suggestions

Search Suggestions

Based on your current searches we recommend the following search filters.

FindAPhD. Copyright 2005-2020
All rights reserved.