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Macromolecules for drug delivery


Department of Chemistry

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Dr L Twyman Applications accepted all year round Self-Funded PhD Students Only

About the Project

We have worked with a number of water soluble polymer systems that are capable of encapsulating and solubilising various hydrophobic drug moieties. Current target areas include cancer and anti-prion treatments. For this project, we propose to develop and synthesise a range of macromolecules that contain internal spaces capable of binding a number of different drugs, including large therapeutic molecules. As such, drugs can be solubilized, protected and delivered to specific sites in the body. Once synthesised the binding and release properties of a number of encapsulated drugs will be tested, along with their therapeutic and biological properties. This aspect of the project will be carried out in collaboration with colleagues in medicine and medicinal chemistry.

References

1. Kadhim A, McKenzie LK, Bryant HE & Twyman LJ; Synthesis and Aggregation of a Porphyrin-Cored Hyperbranched Polyglycidol and Its Application as a Macromolecular Photosensitizer for Photodynamic Therapy. Molecular Pharmaceutics, 2019, 16(3), 1132-1139.
2. Beezer AE, King ASH, Martin IK, Mitchell JC, Twyman LJ & Wain CF; Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives. Tetrahedron, 2003, 59(22), 3873-3880.
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