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Macrophage biology in inflammation

  • Full or part time
    Prof D R Greaves
  • Application Deadline
    Friday, January 11, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Work in the Greaves Laboratory aims to understand how macrophage differentiation contributes to both inflammation initiation and tissue repair. We are particularly interested in developing methods to study the functional properties of macrophages at different sites of inflammation. To do this we have developed new methods to track monocyte recruitment and macrophage differentiation in vivo including hCD68-Gfp transgenic reporter mice (1,2) and developing new real time assays for chemotaxis and phagocytosis (3).
In this project the student will use single cell assays to study how macrophage differentiation in vitro affects phagocytosis of pathogens, efferocytosis of apoptotic cells and cytokine production. This project can be extended to study macrophage differentiation in vivo in different models of inflammation, including mouse models of atherosclerosis.
Our ultimate goal is to identify ways to re-direct macrophage differentiation for therapeutic benefit in chronic inflammation and cardiovascular disease.

Funding Notes

4 Year DPhil Prize Studentships cover University and College fees, a stipend of ~£16,777 pa, and up to £5,300 pa for research costs and travel. The competition is open to applicants from all countries. See View Website for full details and to apply.

References

(1) Iqbal AJ (2014) Blood 124:e33-e44; doi: https://doi.org/10.1182/blood-2014-04-568691
(2) McNeill E, Iqbal AJ et al. (2017) Arterioscler Thromb Vasc Biol. 2017; 37(2):258-263
(3) Kapellos TS et al. Biochem Pharmacol. (2016) 116:107-19. doi: 10.1016/j.bcp.2016.07.011

How good is research at University of Oxford in Biological Sciences?

FTE Category A staff submitted: 223.80

Research output data provided by the Research Excellence Framework (REF)

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