About the Project
The chemical and mechanical properties of the magnetic gels will be tailored to accomplish stability and robustness. The customizable properties together with biocompatibility will allow these materials to be used as wearable devices, capable of drug-release, for both external and sub-epidermal applications. The magnetic component renders remote control actuation as well as the possibility to be activated via hyperthermia. Such a platform can potentially lead to significant improvements in targeted drug delivery, with minimally invasive procedures. Experiments will also be directed to study the scope of biocompatibility using cell-based models, and to investigate the delivery of antibiotics against microbial activity as well as to determine the impact of magnetic fields on cell viability and proliferation.
The research will be supervised by a multidisciplinary team with expertise in Organic & Nano Chemistry, Biochemistry, Microbiology and immunology, and aims to create interdisciplinary links for highly impactful research, targeting healthcare applications. External collaborations include experts in the fields of Chemical Engineering and Mechanical Engineering at University College London.
1. Ayomi S. Perera, Siqi Zhang, Shervanthi Homer-Vanniasinkam, Marc-Olivier Coppens and Mohan Edirisinghe, “Polymer-magnetic composite fibers for remote-controlled drug release”, ACS Appl. Mater. Interfaces 2018, 10, 15524-15531.
Q1 (SJR 2017: 2.78)
2. Ayomi S. Perera, Navaneetha K. Subbaiyan, Mausam Kalita, Michael E. Niederweis, Sebastian O. Wendel, Thilani N. Samarakoon, Francis D'Souza and Stefan H. Bossmann, “A Hybrid Soft Solar Cell Based on the Mycobacterial Porin MspA Linked to a Sensitizer−Viologen Diad”, J. Am. Chem. Soc. 2013, 135, 6842−6845.
Q1 (SJR 2017: 8.13)
3. Ayomi S. Perera and Marc-Olivier Coppens, “Re-designing materials for biomedical applications: from biomimicry to nature-inspired chemical engineering”, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018, 377, 2138.
Q1 (SJR 2017: 0.91)
4. Viloria K, Munasinghe A, Asher S, Bogyere R, Jones L, Hill NJ. A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth. Sci Rep. 2016 Nov 25;6:37839.
Q1 (SRJ 2017: 1.53)
5. Ryall CL, Viloria K, Lhaf F, Walker AJ, King AJ, Jones PM, Mackintosh D, McNeice R, Kocher HM, Flodstrom-Tullberg M, Edling EC, Hill NJ. Novel role for matricellular proteins in the regulation of islet beta cell survival: the effect of SPARC on survival, proliferation and signalling. J Biol Chem. 2014 Oct 31;289(44):30614-24.
Q1 (SJR 2017: 2.67)
6. Bywaters L, Mulcahy-Ryan L, Fielder M, Sinclair A, Le Gresley A.
Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of Staphylococcus aureus. Mol Cell Probes. 2017 Dec;36:1-9. doi: 10.1016/j.mcp.2017.06.006. Epub 2017 Jun 28.
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