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Magnetic-polymer hydrogels for controlled drug release


Faculty of Science, Engineering and Computing

About the Project

This dynamic, multidisciplinary project involves developing a facile technique to fabricate polymer hydrogels incorporated with Fe3O4 magnetic nanoparticles (MNPs) for controlled drug delivery applications. The overall goal is to develop a new drug delivery platform, for efficient, safe and less painful treatment of external wounds. These gels are biocompatibleand can be actuated via an external magnetic field. The porosity and mechanical properties of the gels can be readily customized. Various drug molecules can be mixed into the polymer-MNP solution, prior to gel formation, to generate gel patches infused with known drug quantities. They can be actuated with external magnetic fields to release drugs in a controlled manner. The amount of drug released can be controlled by customizing the physicochemical properties of the gels by varying either the polymer or MNP concentrations, and by layering the gels. Two techniques are proposed to trigger & control drug-release: 1) Hydrogen bonding between citrate coated Fe3O4 MNPs and model drug, 2) Drugs and MNPs loaded onto vesicles such as liposomes.
The chemical and mechanical properties of the magnetic gels will be tailored to accomplish stability and robustness. The customizable properties together with biocompatibility will allow these materials to be used as wearable devices, capable of drug-release, for both external and sub-epidermal applications. The magnetic component renders remote control actuation as well as the possibility to be activated via hyperthermia. Such a platform can potentially lead to significant improvements in targeted drug delivery, with minimally invasive procedures. Experiments will also be directed to study the scope of biocompatibility using cell-based models, and to investigate the delivery of antibiotics against microbial activity as well as to determine the impact of magnetic fields on cell viability and proliferation.
The research will be supervised by a multidisciplinary team with expertise in Organic & Nano Chemistry, Biochemistry, Microbiology and immunology, and aims to create interdisciplinary links for highly impactful research, targeting healthcare applications. External collaborations include experts in the fields of Chemical Engineering and Mechanical Engineering at University College London.

Funding Notes

No funding is avaialble for this PhD

References


1. Ayomi S. Perera, Siqi Zhang, Shervanthi Homer-Vanniasinkam, Marc-Olivier Coppens and Mohan Edirisinghe, “Polymer-magnetic composite fibers for remote-controlled drug release”, ACS Appl. Mater. Interfaces 2018, 10, 15524-15531.
Q1 (SJR 2017: 2.78)

2. Ayomi S. Perera, Navaneetha K. Subbaiyan, Mausam Kalita, Michael E. Niederweis, Sebastian O. Wendel, Thilani N. Samarakoon, Francis D'Souza and Stefan H. Bossmann, “A Hybrid Soft Solar Cell Based on the Mycobacterial Porin MspA Linked to a Sensitizer−Viologen Diad”, J. Am. Chem. Soc. 2013, 135, 6842−6845.
Q1 (SJR 2017: 8.13)

3. Ayomi S. Perera and Marc-Olivier Coppens, “Re-designing materials for biomedical applications: from biomimicry to nature-inspired chemical engineering”, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2018, 377, 2138.
Q1 (SJR 2017: 0.91)

4. Viloria K, Munasinghe A, Asher S, Bogyere R, Jones L, Hill NJ. A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth. Sci Rep. 2016 Nov 25;6:37839.
Q1 (SRJ 2017: 1.53)

5. Ryall CL, Viloria K, Lhaf F, Walker AJ, King AJ, Jones PM, Mackintosh D, McNeice R, Kocher HM, Flodstrom-Tullberg M, Edling EC, Hill NJ. Novel role for matricellular proteins in the regulation of islet beta cell survival: the effect of SPARC on survival, proliferation and signalling. J Biol Chem. 2014 Oct 31;289(44):30614-24.
Q1 (SJR 2017: 2.67)

6. Bywaters L, Mulcahy-Ryan L, Fielder M, Sinclair A, Le Gresley A.
Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of Staphylococcus aureus. Mol Cell Probes. 2017 Dec;36:1-9. doi: 10.1016/j.mcp.2017.06.006. Epub 2017 Jun 28.


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