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Magnetic Resonance Imaging (MRI) Tractomics of Glial Brain Tumours


   Neurosciences, Molecular and Clinical Sciences Research Institute

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  Prof Franklyn Howe, Dr Thomas Barrick, Dr Philip Benjamin  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

This is an exciting opportunity to join a translational MRI research group that is developing quantitative biomarkers to aid diagnosis and prognosis for a wide range of brain pathologies.

In this neuroimaging project the aim is to develop better methods of predicting the future growth of glial brain tumours. Glial tumours are a major challenge to diagnose and treat due to their genetic variability and infiltrative growth patterns that are not accurately defined with routine clinical MRI.

This project will investigate the infiltration of tumours into surrounding white matter using a new diffusion MRI technique – Quasi-Diffusion Imaging (QDI). QDI has been developed at St George’s to maximally utilise 3T MRI technology and heavily diffusion weighted scans, and has high sensitivity to detect pathological damage. QDI will be used to detect white matter tracts within and around the tumour, and develop a tractomic characterisation of damage and infiltration. Machine learning methods will be used to relate this complex data to the patient’s future outcome and develop prognostic biomarkers.

You will join an MR research team of physicists, mathematicians and computer scientists who collaborate with neurosurgeons and neuroradiologists.

You will have a physics and mathematics background, with computer skills and a strong desire to develop new technology into practical clinical tools, that aid the neuro-onocological team provide better treatment for brain tumour patients.

Skills we expect a student to develop/acquire whilst pursuing this project

  • Understanding of the physics of MRI and development of programming skills in Matlab, Unix and specialist image processing software for brain tumour image analysis
  • Basic understanding of brain tumour biology, radiological and pathological diagnostic methods, treatments and patient outcomes.
  • An understanding of pattern recognition and image processing methods and their application to neuroimaging data.
  • Application of statistical methods to evaluate novel MRI data classification algorithms and how to develop image processing pipelines for MRI data.
  • How to interact effectively within a multi-disciplinary team of clinical, biomedical and computer science experts.
  • Understand and comply with ethical and information governance regulations of patient data.
  • Develop skills to effectively present complex image analysis methodology to general scientific and clinical audiences and presentation of results and preparation of papers for expert peer review

Particular prior educational requirements for a student undertaking this project

Minimum 2:1 honours BSc in a scientific discipline with a strong physics and mathematics components: physics, mathematics, engineering, computer science etc. Ideally with an MSc or other research/industry experience that incorporated medical imaging or machine learning as appropriate for the project

Project key words 

Magnetic resonance imaging (MRI), Brain tumour, Machine learning, Quasi-Diffusion Imaging (QDI).

MRC Core Skills developed through this project

Quantitative skills

Interdisciplinary skills

MRC LID themes

Translational and Implementation Research

Further Information

Further information regarding the MRC LID Training Partnership Studentships can be found at https://www.lshtm.ac.uk/. This includes how to apply https://mrc-lid.lshtm.ac.uk/apply/, studentship funding https://mrc-lid.lshtm.ac.uk/funding/, studentship options https://mrc-lid.lshtm.ac.uk/studentship-options/, and eligibility criteria https://mrc-lid.lshtm.ac.uk/eligibility-criteria/.


Funding Notes

Funding is provided as part of the MRC London Intercollegiate Doctoral (MRC LID) Training Partnership Studentships View Website. MRC LID is a partnership between St George’s, University of London and London School of Hygiene & Tropical Medicine.

References

[1] Barrick et al., (2020). Quasi-diffusion magnetic resonance imaging (QDI): A fast, high b-value diffusion imaging technique. NeuroImage, https://pubmed.ncbi.nlm.nih.gov/32032739/.
[2] Henderson et al., (2020). Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential. Neurosurgical Focus, https://pubmed.ncbi.nlm.nih.gov/32006950/.
[3] Mabray et al., (2015). Modern Brain Tumor Imaging.Brain Tumor Research and Treatment, http://dx.doi.org/10.14791/btrt.2015.3.1.8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426283/.
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