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Making Induced Neural Stem Cells from People with Progressive Multiple Sclerosis


Project Description

Multiple sclerosis (MS), an immune-mediated disease of the central nervous system, afflicts an estimated 2-3 million people worldwide, most of whom will ultimately develop a progressive form of the disease with few therapeutic options. In this project we aim to develop the capability to generate clinical grade, patient-specific induced neural stem cells (iNSCs) from people with progressive MS (PMS). Somatic cells have been reprogrammed to stably expandable iNSCs and will be differentiated and monitored for several makers of pluripotency/multipotency, checked for morphological, function and genomic stability. The long-term goal of this project will be to evaluate the safety and therapeutic potential of iNSCs from people with PMS in anticipation for use in clinical trials.

Funding Notes

Funding deadline is 3rd December 2019 for start in October 2020. When applying indicate on the application the funding options (GATES USA *deadline 9/10/19*, Gates Cambridge or other Cambridge Funders). Home/EU and International applications are all considered for funding.

References

Applicants can only be considered if they apply via the applicant portal which can be found at this link; https://www.graduate.study.cam.ac.uk/ please do not send in an enquiry and CV as this will not be considered an application.

Related Subjects

How good is research at University of Cambridge in Clinical Medicine?

FTE Category A staff submitted: 192.05

Research output data provided by the Research Excellence Framework (REF)

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