About the Project
Bivalent cations e.g., magnesium has been shown to stimulate bone growth and healing by regulating the osteoblast, osteoclast and macrophage activity. Mg is also actively involved in the mineralization process which controls bone formation and resorption. However, an excessively high concentration of magnesium is detrimental to osteoblasts and even prevents the formation of the bone extracellular matrix. While Mg ions are naturally found in the human body, it is still unclear why a particular local concentration of Mg is important to the regulation of osteogenesis. Hence, our research team has studied the effects of different concentrations of magnesium on various cell lines including osteoblasts, chondrocytes, and mesenchymal stem cells. The results demonstrate that a specific dosage of magnesium can significantly up-regulate the cellular activities in the cell lines monitored. Hence, our team develops various implantable cation-based bio-composites that enable precise controlled release of magnesium to convince in-situ bone formation. We believe that these discoveries will open up an exciting prospect of using bivalent cations in bone regeneration. This process is potentially cheaper, simpler, and safer than other current approaches.
Kelvin Yeung has been passionate about applied orthopaedic biomaterial research and translation for more than 20 years. His major research areas are the development of orthopedic biomaterials, antibacterial coatings, 3D bio-printing and musculoskeletal tissue engineering. He trained as a materials scientist for his bachelor’s degree and then as an orthopedic scientist in HKU Medical Faculty for his master’s degree and his Ph.D.
He is currently tenured associate professor in the Department of Orthopaedics and Traumatology, The University of Hong Kong. His h-index is 41 (Scopus) with more than 5,800 citations. He has been ranked in the World’s Top 1% of Scientists in the field of biomaterials by Clarivate Analytics’ Essential Science Indicators (ESI) from 2014 to 2018. In addition to publishing 217 peer-reviewed SCI journal papers and filing 38 full patents in various countries, he co-founded OrthoSmart Limited with two senior colleagues to adapt their research findings for clinical use. He currently serves as interim CEO of this startup company. Furthermore, he has been invited to act as a consultant for several medical device and biomaterial corporations.
During these years, he participated in local and regional competitions and received a number of awards and scholarships, including the Young Scientist Award 2005 and the Young Engineer Award 2009. For projects in which he has acted in the capacity of principal investigator or co-principal investigator, he has received over HK$57,170,000. Since 2006, he has supervised 14 Ph.D. and 8 M.Phil. students. Furthermore, he has received 19 prizes and awards from local and international competitions and conferences. He has also been invited to deliver 74 plenary lectures, keynotes or invited talks at international and regional conferences.
Supervisor’s information webpage link: http://hub.hku.hk/cris/rp/rp00309
Faculty information, funding opportunities and application deadlines: https://www.findaphd.com/phds/program/biomedical-research-hku-li-ka-shing-faculty-of-medicine/?i586p4119
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