Manufacture and bioanalysis of nanomedicine prototypes for oligonucleotide drug delivery

Nanomedicine offers a promising strategy for the targeted delivery of oligonucleotide therapies across multiple clinical indications. The nanoparticle manufacturing process is known to impact nanoparticle quality attributes, that subsequently impact upon the quality and biological performance of these products. Understanding the association between particle manufacture process parameters and resultant nanoparticle attributes (size, surface properties, etc) can lead to the rapid and agile design of new nanoparticle prototypes.

This prestigious project is a joint collaboration between the Rattray and Perrie laboratories situated within the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). The aim of this studentship is to ascertain the association between particle critical quality attributes and the biological performance of novel nanomedicine prototypes. In this project, the successful candidate will use world-leading microfluidics-based platforms for the manufacture of oligonucleotide-loaded model prototype nanoparticles (polymeric, lipid) in the Perrie group. The impact of manufacturing parameters on particle critical quality attributes and their interactions with biological media will be investigated. You will use advanced analytical techniques (multiple field flow fractionation modalities hyphenated with analytical detectors) and analysis of their cellular interactions will be performed in the Rattray group. 

This project is ideally suited to highly-motivated and talented students with a keen interest to work at the interface of drug delivery and analytical disciplines. Candidates are expected to possess at least an upper second-class degree (or equivalent) in a relevant Pharmacy, Pharmaceutical Sciences, Biosciences, Chemistry, or Engineering backgrounds. The successful candidate will receive training on a wide range of highly desirable technical skills in the field of drug delivery, including and not limited to, the application of microfluidics technology, field flow fractionation, particle analysis techniques (nanoparticle tracking analysis, Dynamic/Multiangle Light Scattering), 2D/3D cell culture techniques, in vivo, confocal microscopy and image analysis techniques. Additionally, the successful candidate will also benefit from a Postgraduate Certificate in Academic Practice from the University of Strathclyde. The student will benefit from working and interacting with the staff and students in two highly-vibrant and multidisciplinary teams within the SIPBS interdisciplinary environment. The University of Strathclyde is currently ranked second for Pharmacy and Pharmacology in the UK Complete University Guide.

How to Apply:

All enquiries and applications should be directed to Dr Zahra Rattray ([Email Address Removed]). Applications will be reviewed when received, and shortlisted candidates will be invited for an interview. The position will remain open till the advertised deadline.

All applications must be submitted via email (subject line: PhD applicant) as a single pdf file and include the following:

1) A cover letter (max 1 page) explaining your interest and fit to the project

2) A CV (maximum three pages).

3) Names and contact details of TWO references (including email addresses).

4) A copy of your academic transcripts.

Subject line: PhD applicant

Email address: [Email Address Removed]

Due to the ongoing COVID-19 pandemic, any interviews will be conducted on Zoom and there will be flexibility in interview times. The anticipated start date for this studentship is October 2022.