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Marie Skłodowska-Curie Innovative Training Network "PersonalizeAF" - ESR2: Impedance characterization for scar and fibrosis detection

Project Description

“Electrical Engineering and Information Technology” PHD Programme in at Karlsruhe Institute of Technology.

Expected Results: A multi spectral impedance measurement system and catheter will be developed and used to study the relation between the different tissue mutation of the myocardium, especially scar and fibrotic, as means to better characterize the tissue

Objectives: Regions of scar and fibrotic tissue have been identified as a potential driving region of arrhythmic activity during AF. High density mapping in the Electrophysiology Lab (EP-Lab) can deliver important information about areas of low voltage and slow conduction, both characteristics of these driving areas. Impedance measurement can be practically implemented on intracavitary recordings and provide the information required to locate these regions, as changes in conductivity may indicate alterations in myocardium functionality.

Planned secondments: 3; Universitè de Burdeux signal processing for intracardiac fibrosis identification, Institut d’Investigacions Biomèdiques August Pi I Sunyer clinical evaluation of fibrosis, ADAS3D software for clinical evaluation of fibrosis.

About the Project

Atrial Fibrillation (AF) is the most common cardiac arrhythmia affecting more than 6 million Europeans with a cost exceeding 1% of the EU health care system budget (13.5 billion annually). New treatment strategies and the progress achieved in research on AF mechanisms and substrate evaluation methods to date have not been commensurate with an equivalent development of the knowledge and technologies required to individually characterize each patient in search of the most efficient therapy.

PersonalizeAF addresses this challenge by delivering an innovative multinational, multi-sectorial, and multidisciplinary research and training programme in new technologies and novel strategies for individualized characterization of AF substrate to and increase treatments’ efficiency.

From the research point of view, PersonalizeAF will integrate data and knowledge from in-vitro, in silico, ex vivo and in vivo animal and human models to: 1) generate an individual description of the state of the atrial muscle identifying the disease mechanisms and characteristics; 2) understanding the potential effect that different therapies have on different atrial substrates; and 3) combining this information to generate a specific profile of the patient and the best therapy for each patient.

With this purpose, PersonalizeAF partnership aggregates relevant scientific staff from the academic and clinical world with highly specialised biomedical companies which will be involved in a high-level personalised training programme that will train a new generation of highly skilled professionals and guarantee ESRs and future PhD students outstanding Career Opportunities in the biomedical engineering, cardiology services and medical devices sectors. PersonalizeAF will disseminate results to a wide spectrum of stakeholders, create awareness in the general public about atrial fibrillation and encourage vocational careers among young students.

Please see for detailed application instructions.

Funding Notes

The remuneration occurs on the basis of the wage agreement of the civil service in TV-L E13. Employer social security contributions will be deducted.


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