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Mass spectrometric imaging of biological tissues

Project Description

Mass spectrometry imaging (MSI) exploits the ability of mass spectrometry to identify molecules according to their specific mass and image their distribution across the sample. The method allows direct visualization of endogenous compounds (lipids, proteins, saccharides) as well as exogenous drugs and their metabolites. The aim of the research will be development of a suitable matrix-assisted laser desorption/ionization (MALDI) MSI method for the study of distribution and the effect of chosen drug selected tissues and cell lines. Special attention will be devoted to sample preparation and matrix deposition (spray, sublimation, piezoelectric dispenser). The samples will be supplied by cooperating institutions (e.g. the Department of Experimental Biology, Experimental and Applied Neuropsychopharmacology, Centre for Neuroscience, the Department of Pharmacology, the Regional Centre for Applied Molecular Oncology). The analyzed compounds include endogenous compounds (lipids, glycans) as well as selected drugs.

RG: Jiří Pinkas Research Group

Keywords: mass spectrometry imaging, MSI, matrix-assisted laser desorption/ionization,MALDI, analysis development

Applicants who wish to pursue a degree at the CEITEC PhD programme must hold the equivalent of a Master’s degree (MSc) in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five month after the application deadline.

Funding Notes

Admission for studies, student registration for the full-time study programme and proper fulfilment of student duties constitute the student’s right to a regular scholarship of 22 000 CZK (850 EUR). Information is available at View Website

Living costs and other practicalities available at View Website

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