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Mast cell dysregulation? Understanding the development of mastocytosis


Project Description

Project details:

Mastocytosis is a myeloproliferative disease characterised by the accumulation of neoplastic mast cells in one or several organs that can result in organ failure. The majority of adult patients with mastocytosis present with systemic mastocytosis (SM). Despite advances in the understanding of myeloid neoplasia, the aetiology of mastocytosis is poorly understood. 80-90% of mastocytosis patients harbour a somatic activating mutation in the c-KITgene (D816V). However, the presence of the c-KITmutation does not explain the heterogeneous clinical behaviour of the disease. We will use high resolution proteomics-mass spectrometry to elucidate the molecular mechanisms involved in mastocytosis. This project will generate permanent digital proteomics maps from mastocytosis patients enabling the key signalling molecules involved in mastocytosis pathogenies to be identified and characterised.

This project will be supervised by Dr Ciaren Graham, Dr Bobby Graham, and Professor Chris Creevey of Queen’s University School of Biological Sciences.

All applications MUST be submitted through https://dap.qub.ac.uk/portal/user/u_login.php.

Specific skills/experience required by applicants:

Good molecular biology experience. Experience of tissue culture would be advantageous.

All applicants must meet the academic entry requirements: https://www.qub.ac.uk/courses/postgraduate-research/biological-sciences-phd.html#entry

Funding Notes

Only UK and EU students are eligible to apply. Before applying, it is strongly recommended that you read the full information on eligibility criteria available from DfE: View Website.

Please note in particular that not all successful applicants may be eligible to receive a full studentship (i.e. fees and stipend) - please read in detail the Residency and Citizenship requirements in the document linked to above.

How good is research at Queen’s University Belfast in Public Health, Health Services and Primary Care?

FTE Category A staff submitted: 29.60

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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