MASTERS BY RESEARCH PROJECT: Dissecting principles of long-range neuronal connectivity in mammalian motor circuits

Start 23 September 2019


This MSc by Research is a laboratory-based project which offers the exciting opportunity to spend 1 year in one of our State-of-the-Art laboratories (plus 1 year thesis writing) at the University of Bristol and experience life as a researcher. You will be working with one of our cutting-edge research groups where you will learn new skills and techniques, including experimental design and implementation, data analysis and scientific writing.

Brain function relies upon specific patterns of wiring between individual neurons. Neurons connect via their axons to other cells in their vicinity (locally) and also to other brain regions (long-range). Both types of connection can be exquisitely precise, but we have much to learn about the logic of neuronal connectivity from one region to another. This issue is particularly pressing in the cerebellum (or ‘little brain’) which is composed of three discrete structures (cortex, nuclei and inferior olive) that are linked via long-range projections. The aim of this project is to map projection patterns of single cells from the cerebellar cortex to the nuclei using molecular tools (e.g. genetically encoded fluorescent proteins) [1,2] to determine the rules governing connectivity between these two regions [3].

You will join a dynamic and multidisciplinary team who apply a range of approaches (2-photon imaging, high density electrophysiological recording, patch clamp, computational modelling) to understand mechanisms of motor control and learning in the intact brain. During this project, there will be opportunities to collaborate with group members to gain experience of other in vivo techniques and to present your work at international conferences.

For more information, please contact Paul Chadderton ([Email Address Removed]).

http://www.neuralcircuitsinbehaviour.org

Please visit the UOB/faculty of Life Sciences/ School of Physiology, Pharmacology and Neuroscience/ postgraduate studies website for the complete list of available MSc by Research projects.