Cardiovascular diseases are the worlds’ leading cause of death. Dietary approaches to prevent or treat these diseases are becoming increasingly accepted. Phytochemicals such as polyphenols show promise in reducing cardiovascular disease risk, however exactly how they work is not known. This project would involve undertaking experiments to try to elucidate the mechanisms by which polyphenols improve cardiovascular parameters and to identify and test methods (e.g. nutrient synergy or food processing) to maximise their efficacy. The project would offer training opportuinities in both in vitro and in vivo research within the internationally recognised Hugh Sinclair Unit of Human Nutrition, University of Reading, UK.