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(MCRC Clinical) Creating and annotating a digital pathology atlas for primary and metastatic PDA


Faculty of Biology, Medicine and Health

About the Project

Pancreatic Ductal Adenocarcinoma (PDA) is a dismal disease with late detection, limited treatment option and poor outcome. A hallmark of PDA is an extensive desmoplastic reaction where stromal cells, such as immune cells and cancer-associated fibroblasts, provide a pro-tumorigenic environment. While much effort is aimed at targeting the desmoplasia, little is known of the compositional variation across patients and which markers can be optimally used for patient stratification. In this project, we aim to implement workflows to analyse stromal cell populations across patients and with the aim of developing a digital (stromal) pathology atlas for patient stratification. The fellow will be based in a highly collaborative environment across CRUK Manchester Institute, MCRC, Christie Foundation Trust and MFT Foundation Trust and will also collaborate across Precision-Panc.

Entry Requirements:
Candidates must be post-registration clinicians and ideally, have a specialist post in a related subject. It is generally expected that CRTFs would return to a training programme in the UK upon completion of their research degree.

UK applicants interested in this project should make direct contact with the Primary Supervisor to arrange to discuss the project further as soon as possible. International applicants (including EU nationals) must ensure they meet the academic eligibility criteria (including English Language) as outlined before contacting potential supervisors to express an interest in their project. Eligibility can be checked via the University Country Specific information page (https://www.manchester.ac.uk/study/international/country-specific-information/).

If your country is not listed you must contact the Doctoral Academy Admissions Team providing a detailed CV (to include academic qualifications – stating degree classification(s) and dates awarded) and relevant transcripts.

Following the review of your qualifications and with support from potential supervisor(s), you will be informed whether you can submit a formal online application.

To be considered for this project you MUST submit a formal online application form - full details on how to apply can be found on the CRUK Manchester Centre PhD Training Scheme (MCRC) website https://www.bmh.manchester.ac.uk/study/research/funded-programmes/mcrc-training-scheme/

General enquiries can be directed to .

Equality, diversity and inclusion is fundamental to the success of The University of Manchester and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/

Interview date – 8 January 2021

Funding Notes

The clinical fellowships are usually tenable for three years, although in certain circumstances they may be four years duration. We will provide running expenses, an appropriate salary in line with the applicant’s current salary and grade, and full coverage of University UK PhD fees. The University of Manchester aims to support the most outstanding applicants from outside the UK. Due to the competitive nature of this scheme, we are only able to offer a limited number of tuition fee bursaries to be awarded to international candidates of exceptional quality.

Four year project. Entry point: April 2021 or October 2021.

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