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(MCRC Clinical) Developing circulating and imaging biomarkers towards personalised radiotherapy in lung cancer

Project Description

Project summary:
Approximately a third of Non-Small Cell Lung Cancer cases are locally-advanced (LA-NSCLC) at presentation (~13,000 pts a year in the UK) with the majority being unsuitable for curative surgery. These patients rely on thoracic radiotherapy (often given in combination with chemotherapy) as their only chance of cure. Unfortunately this treatment can be toxic for the patient to endure and the prognosis is poor, either due to poor local control or occult metastasis. In LA-NSCLC treatment and follow-up are currently performed in a ‘one-size-fits-all’ manner. To improve the management of these patients treated with radiotherapy and systemic therapy there is an unmet clinical need to develop biomarkers to identify poor responders, predict benefit from treatment and diagnose relapse before standard of care imaging.

This project will capitalise on local expertise in non-invasive biomarkers, clinical trial and radiotherapy big data infrastructure and cancer biology to offer a unique opportunity to make translational advances in the management of NSCLC. The project will focus on a clinical trial schema using circulating biomarkers and radiomics in LA-NSCLC patients before, during, and following radical chemo-radiotherapy. These data will be combined with clinical outcome and unique work done at The Christie with patient reported outcome measures (PROMs) to understand the utility of circulating and imaging biomarkers to individualise care.

Overall this project builds on the individual strengths of the CRUK Lung Cancer Centre of Excellence, Manchester Centre for Cancer Biomarkers and the MCRC to bring together studies of clinical utility and give the student grounding in the circulating and imaging biomarker advances that will improve the stratification of patients’ in future clinical trials.

Entry Requirements:
Candidates must be post-registration clinicians and ideally have a specialist post in a related subject, for example, obstetrics and gynaecology, oncology, or primary care. Applicants must have been resident and worked within the EEA (European Economic Area) for at least three years prior to application.

Funding Notes

The clinical fellowships are usually tenable for three years, although in certain circumstances they may be four years duration. We will provide running expenses, an appropriate salary in line with the applicant’s current salary and grade, and full coverage of University PhD fees. Where international student fees are payable, please provide evidence with your application of how the shortfall will be covered (approximately £19,000 per annum).

The length of this project will be THREE YEARS.

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