People with Multiple Long-Term Conditions (MLTC) show increased susceptibility to external stressors like infection, trauma, or surgery, where they are at increased risk of organ injury affecting the heart, lungs, kidneys, and brain, and death, versus those without MLTC. Identification of the processes underlying increased susceptibility to external stressors in people with MLTC is an international research priority.
In our previous work we have identified changes in immune system activation within organs including the heart as important determinants of outcome. It is necessary to develop accurate diagnostic tests so that these processes can be reversed or prevented with targeted treatments.
The aim of this project will be to use high precision -omics to characterise immune system activation in blood and heart tissue simultaneously in individuals. Then, using informatics analyses we will identify molecular signatures that can be measured by diagnostic tests, and/or druggable targets for new treatments.
The aim of the studentship is to develop familiarity with the most modern research techniques who will have skill sets of value to world class research groups as early career researchers.
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject. The degree needs to be within the broad field of biological sciences.
The University of Leicester English language requirements apply.
Project enquiries to Professor Gavin Murphy [Email Address Removed]
Please email enquiries to [Email Address Removed]
Please follow the application advice and use the application link at https://le.ac.uk/study/research-degrees/funded-opportunities/cvs-murphy