Dr J Sanderson, Dr S Sami, Prof David Broadway
No more applications being accepted
Funded PhD Project (European/UK Students Only)
About the Project
The retina shares it developmental origins with the brain, and may be vulnerable to the same neurodegenerative processes that affect it. Recent advances in ophthalmologic imaging have opened up a new frontier in the study of dementia and the central nervous system.
The PhD project will build on recent developments in ophthalmology, neuroscience and artificial intelligence with the aim of developing improved diagnostic models of healthy ageing and transitions into cognitive decline that will subsequently help improve dementia diagnosis.
This project is part of is a multidisciplinary collaboration between several teams aiming to determine the effectiveness of retinal imaging as a biomarker for early diagnosis of dementia. The work will require the prospective PhD candidate to actively, collaborate with pre-clinical research groups at the University of East Anglia, and the Norfolk & Norwich Hospital.
Entry Requirements: The applicant should have:
- A BSc or MSc in Engineering, Computer Science, Neuroscience or comparable degree.
- Good programming skills, experience in at least one of the following: MATLAB, Python, and Java/C++.
- Background in imaging and image/ time series analysis (preferably with experience in retinal imaging /image analysis).
- Knowledge of Machine learning techniques
- Excellent command of written and spoken English
For more information on the supervisors for this project, please go here:
https://people.uea.ac.uk/j_sanderson
https://people.uea.ac.uk/s_sami
The type of programme: PhD
The start date of the project: October 2019
Mode of study: Full-time
Funding Notes
This PhD studentship is jointly funded for three years by Faculty of Science and Norwich Medical School. Funding comprises home/EU tuition fees, an annual stipend of £15,009 and £1000 per annum to support research training. Applications are open to UK/EU applicants only.
Entry requirements: Minimum entry requirement is 2:1.
References
i) Sami S, Hughes LE, Williams N, Cope T, Henson R, Rowe JB Neurophysiological signatures of Alzheimer’s disease and Frontotemporal lobar degeneration: pathology versus phenotype Brain. 2018;141(8):2500-2510.
ii) Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KS, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS, Arnold R, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB. 18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. Brain. 2017 Mar 1;140(3):781-791.
iii) Niyadurupola N, Sidaway P, Osborne A, Broadway DC, Sanderson J. (2011) The development of human organotypic retinal cultures (HORCs) to study retinal neurodegeneration. Br. J. Ophthalmol. 10: 720-726.
iv) Osborne A, Hopes M, Wright P, Broadway DC, Sanderson J (2016) Human Organotypic Retinal Cultures (HORCs) as a Chronic Experimental Model for investigation of Retinal Ganglion Cell Degeneration. Exp. Eye Res. 143: 28–38.
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