FREE PhD Study Fairs in Sheffield & Edinburgh | REGISTER NOW FREE PhD Study Fairs in Sheffield & Edinburgh | REGISTER NOW

Mechanisms of plasma membrane proteostasis in neuroscience


   School of Biochemistry

This project is no longer listed on FindAPhD.com and may not be available.

Click here to search FindAPhD.com for PhD studentship opportunities
  Dr Adam Grieve  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Many human diseases are caused by dysregulation of plasma membrane (PM) proteins, yet the mechanisms that cells use to monitor PM protein activity and abundance (proteostasis) are unclear. The focus of our newly established lab at the School of Biochemistry, University of Bristol, is the mechanistic investigation of PM proteostasis. In particular, we are interested in intramembrane proteolysis, a process whereby PM proteins are downregulated by transmembrane domain cleavage1–3.

We are seeking an ambitious student to drive a multidisciplinary project aimed at the discovery and investigation of new substrates for neuronal intramembrane proteases at the PM. Prior knowledge and experience of membrane protein biology, trafficking and signalling is desirable; a conscientious work ethic and good communication skills are essential. The project will be largely shaped by the interests and skills of the successful applicant and is likely to employ a combination of biochemistry, proteomics, bioinformatics and molecular cell biology. Ultimately, the findings from this project will shed light on how intramembrane proteases regulate neuronal signalling in health and disease.

Please note that this PhD studentship at University of Bristol is fully funded for home fees and stipend at UKRI rate. International applicants are required to cover the difference between home and overseas fees. Start date is 19 September 2022.

For further information/informal enquiries, please email [Email Address Removed].

Twitter: @adam_grieve

Website: grieve-lab.com


Funding Notes

Please note that this PhD studentship at University of Bristol is fully funded for home fees and stipend at UKRI rate. International applicants are required to cover the difference between home and overseas fees. Start date is 19 September 2022.
Please use the link here for information on how to apply online: https://www.bristol.ac.uk/study/postgraduate/apply/
Please ensure you supply all supporting documents to your application: CV / personal statement / BSc and MSc degree transcripts and certificates / 2 academic references. Please also name Dr Grieve as supervisor on the application form

References

1. Urban, S. SnapShot: Cartography of Intramembrane Proteolysis. Cell 167, 1898-1898.e1 (2016).
2. Kühnle, N., Dederer, V. & Lemberg, M. K. Intramembrane proteolysis at a glance: from signalling to protein degradation. J Cell Sci 132, (2019).
3. Grieve, A. G. et al. Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation. Molecular Cell 81, (2021).
Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.

PhD saved successfully
View saved PhDs