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Sheffield Hallam University Featured PhD Programmes
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Mechanisms of transcription regulation by chromatin modification


School of Biochemistry

Wednesday, August 12, 2020 Competition Funded PhD Project (Students Worldwide)

About the Project

Complex programmes of transcription defines every aspect of cellular function and their misregulation1 leads to the widest spectrum of human disease, from cancer to neurological and autoimmune disorders. In eukaryotes, RNA polymerase II (Pol II) synthesises messenger RNAs that are translated into proteins. However, Pol II requires dozens of additional large protein complexes that carefully regulate its activity, and allow it to transcribe through chromatin2. Our goal is to understand the interplay between transcription factors, Pol II3 and chromatin modifying complexes4, and uncover fundamental molecular mechanisms of transcription and its regulation. Our lab uses structural biology together with biochemistry, biophysics, genomics and cell biology to understand the molecular mechanisms of these large macromolecular machines.

This 3-year PhD studentship will focus on understanding the molecular mechanisms of chromatin modifying complexes and their effects on transcription and DNA repair. It will provide state-of-the-art training in structural biology, biochemistry, biophysics and genomics.

We are a dynamic, international research group based in the School of Biochemistry (https://cheunglab.net). The University of Bristol is a centre for structural and cell biology research in health and disease, and the student will benefit from exposure to diverse research topics in this area. Bristol is an exciting and culturally diverse city, with excellent transport links to cities across the UK and Europe.

To apply online, please click on "Institution Website"
When completing the online application form, please choose the following options:
Faculty: Life Sciences and Programme: Biochemistry (PhD)
Applicants must apply via the University of Bristol online application system, and state the supervisor’s name in their application under the relevant section.

Funding Notes

Overseas applicants outside of the UK and EU may apply but should note that they are eligible only to receive the maintenance stipend and tuition fees paid at the home/EU rate. Such applicants will therefore need to fund the difference in fees between the home/EU rate (£4,365 for academic year 2020/2021) and the overseas rate (£23,200).

References

1. Lee, T. I. & Young, R. A. Transcriptional Regulation and Its Misregulation in Disease. Cell 152, 1237–1251 (2013).
2. Li, B., Carey, M. & Workman, J. L. The Role of Chromatin during Transcription. Cell 128, 707–719 (2007).
3. Cheung, A. C. M. & Cramer, P. A Movie of RNA Polymerase II Transcription. Cell 149, 1431–1437 (2012).
4. Díaz-Santín, L. M., Lukoyanova, N., Aciyan, E. & Cheung, A. C. Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution. Elife 6, e28384 (2017).

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