About the Project
In this project the student will generate and analyse mathematical/computational models of the PAR polarity network. The student will first model the simplistic interactions in order to become familiar with modelling techniques. They will then expand the simple model to include more complex published data. This will enable the student to further their modelling skills and become familiar with the biological literature. The student will work in close collaboration with the Rodriguez Lab, who will be performing the experiments within the project. The student will use modelling to help understand biological data, uncover biological mechanism, predict the outcome of experiments and aid experimental design.
Applicants should have a degree in mathematics, physics or computer science. Students with other degrees must have strong evidence of interest and achievement in mathematics and/or computation.
Assistance will be given to those who are applying to international funding schemes.
The successful applicant will be expected to provide the funding for tuition fees and living expenses.
A fee bursary may be available for well qualified and motivated applicants.
Details of costs can be found on the University website:
Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit (Journal article)
Kuo, C. -C., Savage, N. S., Chen, H., Wu, C. -F., Zyla, T. R., & Lew, D. J. (2014). Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit. CURRENT BIOLOGY, 24(7), 753-759. doi:10.1016/j.cub.2014.02.024
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