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Medicinal Chemistry Optimisation of Novel Heterocyclic Anti-infective Agents

Department of Chemistry

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Prof Paul O'Neill , Dr WD Hong No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

The Medicinal Chemistry Groups at Liverpool is one of Europe’s leading academic groups focused on early stage drug discovery. Through the establishment of public private partnerships with major pharma and organisations such as the Medicines for Malaria Venture (MMV) and TB Alliance many of these early stage projects have been developed to the point of candidate selection and clinical trials in humans. We study a wide range of therapeutic areas focussed on antimalarial, antibacterial (Anti-Wolbachia), anti-tuberculous agents with more recent studies focused in the pain, pancreatitis and anti-fungal areas. There are four main research themes that include: (1) Drug Design of New Antimicrobial Agents; (2) Molecular Modelling and Cheminformatics; (3) Safe-Drug Design; (4) Semi-synthetic Natural Product Drug Design.


This PhD will be focused on one of our infectious disease areas and will involve medicinal chemistry optimization with close collaboration with the Liverpool School of Tropical Medicine.

We are looking for an enthusiastic and highly motivated candidate with strong background in medicinal and/or organic chemistry who have, or expect to have, at least a 2:1 degree or equivalent in Chemistry. Additional background in relevant areas, i.e. infectious diseases drug discovery or AMR is desirable. The successful candidate will join in a dynamic team of medicinal chemists, pharmacologists and parasitologists and receive training in synthetic organic chemistry, medicinal chemistry, computational chemistry and parasitology under a team of supervisors from both the University of Liverpool and Liverpool School of Tropical Medicine (Professor Giancarlo Biagini, LSTM).

Some teaching duties may be required and would be paid on top of the standard studentship.

For any enquiries please contact: Professor Paul M. O’Neill ([Email Address Removed])

To apply for this opportunity please visit: Please quote reference CCPR018 in the finance section of the online application form. Please note if you have not heard from us by 26th April 2021 then you have not been successful on this occasion.

Funding Notes

This studentship is funded by the EPSRC DTP scheme and is offered for 3.5years in total. It provides full tuition fees and a stipend of approx. £15,609 tax free per year for living costs. The stipend costs quoted are for students starting from 1st October 2021 and will rise slightly each year with inflation.
The funding for this studentship also comes with a budget for research and training expenses of £1000 per year, and for those that are eligible, a disabled students allowance to cover the costs of any additional support that is required.
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