Medicinal Chemistry Optimisation of Novel Heterocyclic Anti-infective Agents

The Medicinal Chemistry Groups at Liverpool is one of Europe’s leading academic groups focused on early stage drug discovery. Through the establishment of public private partnerships with major pharma and organisations such as the Medicines for Malaria Venture (MMV) and TB Alliance many of these early stage projects have been developed to the point of candidate selection and clinical trials in humans. We study a wide range of therapeutic areas focussed on antimalarial, antibacterial (Anti-Wolbachia), anti-tuberculous agents with more recent studies focused in the pain, pancreatitis and anti-fungal areas. There are four main research themes that include: (1) Drug Design of New Antimicrobial Agents; (2) Molecular Modelling and Cheminformatics; (3) Safe-Drug Design; (4) Semi-synthetic Natural Product Drug Design.

This PhD will be focused on one of our infectious disease areas and will involve medicinal chemistry optimization with close collaboration with the Liverpool School of Tropical Medicine.

We are looking for an enthusiastic and highly motivated candidate with strong background in medicinal and/or organic chemistry who have, or expect to have, at least a 2:1 degree or equivalent in Chemistry. Additional background in relevant areas, i.e. infectious diseases drug discovery or AMR is desirable. The successful candidate will join in a dynamic team of medicinal chemists, pharmacologists and parasitologists and receive training in synthetic organic chemistry, medicinal chemistry, computational chemistry and parasitology under a team of supervisors from both the University of Liverpool and Liverpool School of Tropical Medicine (Professor Giancarlo Biagini, LSTM).

Some teaching duties may be required and would be paid on top of the standard studentship.

For any enquiries please contact: Professor Paul M. O’Neill ([Email Address Removed])

To apply for this opportunity please visit: https://www.liverpool.ac.uk/study/postgraduate-research/how-to-apply/ Please quote reference CCPR018 in the finance section of the online application form. Please note if you have not heard from us by 26th April 2021 then you have not been successful on this occasion.