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Mesoscopic biomolecular oscillator as a novel biomedical sensor platform


   School of Chemistry

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  Prof T Albrecht  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

Biomedical sensing is an area of wide-ranging importance with significant fundamental and applied research that continues to push the limits, in terms of analytical targets, sensitivity, robustness and versatility. Resistive-pulse sensors, such as solid-state nanopores and nanopipettes, are particularly interesting here, because they are a class of single-molecule sensors with unique capabilities and they can be augmented using engineered and functional DNA nanostructures ("carrier-enhanced" resistive-pulse sensing).

In this project, we will expand this concept, using DNA nanotechnology and self-assembly, to create novel "mesocopic" devices, where sensor readout is performed multiple, potentially thousands of times, to achieve unprecedented levels of accuracy and reproducibility.

This is a highly interdisciplinary project, involving nanofabrication, DNA self-assembly, electronics, automation and advanced data analysis. The ideal candidate would therefore have a background in chemistry or physics, or in a related area, be collaborative and importantly should have willingness and enthusiasm to be challenged and learn new things. Previous coding experience in Matlab or Python is advantageous, but not a must.

If you have any questions or would like to request further information, please get in touch via email ([Email Address Removed]) or check out our group website at https://albrechtlab.com/

For information on how to apply, please visit our home page at the link below: https://www.birmingham.ac.uk/postgraduate/courses/apply-pg/index.aspx


Funding Notes

The PhD position is funded at the standard rate and includes bursary and fees at the home level.

References


T Albrecht, "Single-molecule analysis with solid-state nanopores", Annual Review of Analytical Chemistry 2019 12, 371-387 (https://www.annualreviews.org/doi/abs/10.1146/annurev-anchem-061417-125903)
AYY Loh et al., "Electric Single-Molecule Hybridization Detector for Short DNA Fragments" Analytical Chemistry 20187, 90 (23), 14063-14071 (https://pubs.acs.org/doi/abs/10.1021/acs.analchem.8b04357)
RL Fraccari et al., "High-speed detection of DNA translocation in nanopipettes", Nanoscale 2016, 8 (14), 7604-7611 (https://pubs.rsc.org/en/content/articlehtml/2016/nr/c5nr08634e)

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