About the Project
Data from human longitudinal studies and animal models suggest a causative role for vitamin B12 in the development of insulin resistance, small for gestational age and metabolic syndrome phenotype in the offspring. Our preliminary analysis in white pregnant women showed B12 deficiency rates were 20% at 16-18 weeks of gestation and 40% at delivery. Maternal B12 predicts higher lipids in cord blood after controlling for maternal BMI and birth weight. Our findings therefore may represent a reflection of insulin resistance caused either by the dysfunctional placenta or adipose tissue.
Our study aims to investigate that low maternal B12 levels could alter epigenetic mechanisms either though methylation or miRNAs and could have profound effect on tissue-specific gene expression. This study will contribute in understanding the role of micronutrients on the health of the mother and their babies and would offer novel opportunities to reduce the risk of metabolic disease in next generation.
To test these hypotheses, the projects will provide unique opportunities to work with various techniques such as cell culture with different cell models, molecular cell biology – DNA, RNA isolation, reverse transcription, gene expression analysis using quantitative real time PCR (Q-PCR), protein characterisation using western blot, mass spectrometric analysis, methylation and miRNA analysis. The student will be embedded within a dynamic, vibrant and supportive research group to gain training in these techniques - cell culture, molecular biology and omics technologies.
Applicants should have demonstrated excellence at an undergraduate level and/or master’s degree (or UK degree equivalent according to NARIC) with a minimum of a commendation, and/or a UK 1st Class/2.1 in Cell Biology, Molecular Biology, Biochemistry, Biomedical Sciences or any related biosciences subject and have good knowledge of core areas of biosciences.
To apply, please visit https://www.ntu.ac.uk/research/research-degrees-at-ntu/how-to-apply
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.
The interplay between metabolic factors, inflammation and anti-rheumatic drugs with cardiovascular and respiratory associated morbidity and mortality in people with rheumatoid arthritis
The University of Manchester